• Product NameBGT226 (NVP-BGT226)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBGT226 (NVP-BGT226) is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
• Target NamePI3K inhibitor
• CAS No. 1245537-68-1
• Calculated MW 650.6
• Formulation C28H25F3N6O2.C4H4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OC(=O)\C=C/C(O)=O.COC1=CC=C(C=N1)C1=CC=C2N=CC3=C(N(C(=O)N3C)C3=CC=C(N4CCNCC4)C(=C3)C(F)(F)F)C2=C1 |c:11,13,20,41,49,t:9,16,18,22,30,32|
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ
  Boling pt:
  Melting pt:
  Solubility:DMSO:30 mg/mL (46.11 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Markman B, et al. Ann Oncol, 2012, 23(9), 2399-2408.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting