• Product NameEPZ015666
• Brief DescriptionInhibitors
• Purification99.92%
• Biological ActivityEPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1616391-65-1
• Calculated MW 383.44
• Formulation C20H25N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O
  Pathways:Chromatin/Epigenetic
  Receptor:PRMT5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 48 mg/mL warmed (125.18 mM); DMSO: 60 mg/mL warmed (156.47 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Penebre et al. Epizyme, Inc.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting