• Product NameSaracatinib (AZD0530)
• Brief DescriptionInhibitors
• Purification98.31%
• Biological ActivitySaracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 2/3.
• Target NameBcr-Abl inhibitor; BTK inhibitor; c-Kit inhibitor; EGFR inhibitor; Ephrin Receptor inhibitor; Src inhibitor
• CAS No. 379231-04-6
• Calculated MW 542.03
• Formulation C27H32ClN5O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CCOC2=CC(OC3CCOCC3)=C3C(NC4=C(Cl)C=CC5=C4OCO5)=NC=NC3=C2)CC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; JAK/STAT signaling
  Receptor:v-Abl; BLK; c-Kit; EGFR; EGFR (L858R); EGFR (L861Q); EphA2; c-Src; c-Yes; FGR; Fyn; Lck; Lyn; Lyn
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 31 mg/mL (57.19 mM); DMSO: 35 mg/mL warmed (64.57 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chang YM, Oncogene, 2008, 27(49), 6365-6375.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting