• Product NameNVP-AEW541
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM, greater potency and selectivity for IGF-1R in a cell-based assay.
• Target NameFLT inhibitor; IGF-1R inhibitor; Tyrosine Kinases inhibitor
• CAS No. 475489-16-8
• Calculated MW 439.55
• Formulation C27H29N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC=NC2=C1C(=CN2[C@@H]1C[C@H](CN2CCC2)C1)C1=CC(OCC2=CC=CC=C2)=CC=C1 |r,c:3,5,8,30,32,34,36,t:1,23,28|
  Pathways:Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
  Receptor:FLT1; FLT3; IGF-1R; Insulin Receptor; Tek
  Boling pt:
  Melting pt:
  Solubility:DMSO:88 mg/mL (200.2 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. García-Echeverría C, et al. Cancer Cell. 2004, 5(3), 231-239.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting