• Product NameSSR128129E
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.
• Target NameFGFR inhibitor
• CAS No. 848318-25-2
• Calculated MW 346.31
• Formulation C18H15N2O4Na
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:[Na+].COC1=C2C=CC=CN2C(C(=O)C2=CC(C([O-])=O)=C(N)C=C2)=C1C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1
  Boling pt:
  Melting pt:
  Solubility:Water: 1 mg/mL (2.88 mM); DMSO: 69 mg/mL (199.24 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Bono F, et al. Y Cell. 2013, 23(4), 477-488.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting