• Product NameLY2603618
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLY2603618 is a selective Chk1 inhibitor with potential anti-tumor activity. Phase 2.
• Target NameChk inhibitor; PDK inhibitor
• CAS No. 911222-45-2
• Calculated MW 436.3
• Formulation C18H22BrN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[C@@H]3CNCCO3
  Pathways:Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
  Receptor:Chk1; PDK1
  Boling pt:
  Melting pt:
  Solubility:DMSO:13 mg/mL (29.79 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dai Y, et al. Clin Y Res, 2010, 16(2), 376-383.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting