• Product NamePF-543
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform.
• Target NameS1P Receptor inhibitor
• CAS No. 1415562-82-1
• Calculated MW 465.6
• Formulation C27H31NO4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CC1=CC(CS(=O)(=O)C2=CC=CC=C2)=CC(OCC2=CC=C(CN3CCC[C@@H]3CO)C=C2)=C1 |r,c:10,12,14,32,34,t:1,8,19,21|
  Pathways:GPCR/G Protein
  Receptor:SphK1; SphK1
  Boling pt:
  Melting pt:
  Solubility:DMSO:93 mg/mL (199.74 mM)Ethanol:93 mg/mL (199.74 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Schnute ME, et al. Biochem J, 2012, 444(1), 79-88.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting