• Product NameVX-745
• Brief DescriptionInhibitors
• Purification99.75%
• Biological ActivityVX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
• Target Namep38 MAPK inhibitor
• CAS No. 209410-46-8
• Calculated MW 436.26
• Formulation C19H9Cl2F2N3OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:FC1=CC(F)=C(SC2=NN3C=NC(=O)C(=C3C=C2)C2=C(Cl)C=CC=C2Cl)C=C1
  Pathways:MAPK
  Receptor:p38α; p38β
  Boling pt:
  Melting pt:
  Solubility:DMSO:15 mg/mL (34.38 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Duffy JP, et al. ACS Med Chem Lett. 2011 Jul 28;2(10):758-63.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting