• Product NameBelnacasan (VX-765)
• Brief DescriptionInhibitors
• Purification98.45%
• Biological ActivityBelnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Phase 2.
• Target NameCaspase inhibitor
• CAS No. 273404-37-8
• Calculated MW 509
• Formulation C24H33ClN4O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
  Pathways:Apoptosis; Proteases/Proteasome
  Receptor:Caspase-1; Caspase-4
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL warmed (196.46 mM); DMSO: 100 mg/mL warmed (196.46 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wannamaker W, et al. J Pharmacol Exp Ther. 2007, 321(2), 509-516.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting