• Product NameCP-673451
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.
• Target Namec-Kit inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 343787-29-1
• Calculated MW 417.5
• Formulation C24H27N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COCCOC1=CC=C2N(C=NC2=C1)C1=NC2=C(C=CC=C2C=C1)N1CCC(N)CC1 |c:10,13,20,22,25,t:5,7,16,18|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; PDGFRα; PDGFRβ; VEGFR1; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO:28 mg/mL warmed (67.06 mM)Ethanol:4 mg/mL (9.58 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Roberts WG, et al. Cancer Res, 2005, 65(3), 957-966.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting