• Product NameAZD8931 (Sapitinib)
• Brief DescriptionInhibitors
• Purification99.83%
• Biological ActivityAZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
• Target NameEGFR inhibitor
• CAS No. 848942-61-0
• Calculated MW 473.93
• Formulation C23H25ClFN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC(=O)CN1CCC(CC1)OC1=C(OC)C=C2N=CN=C(NC3=C(F)C(Cl)=CC=C3)C2=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2/ErbB2; HER2/ErbB2
  Boling pt:
  Melting pt:
  Solubility:DMSO:40 mg/mL (84.4 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hickinson DM, et al. Clin Y Res, 2010, 16(4), 1159-1169.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting