• Product NameAZD7762
• Brief DescriptionInhibitors
• Purification99.19%
• Biological ActivityAZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
• Target NameChk inhibitor
• CAS No. 860352-01-8
• Calculated MW 362.42
• Formulation C17H19FN4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC(=O)NC1=C(SC(=C1)C1=CC(F)=CC=C1)C(=O)N[C@H]1CCCNC1 |r,c:7,13,15,t:4,10|
  Pathways:Cell Cycle/Checkpoint
  Receptor:Chk1; Chk2
  Boling pt:
  Melting pt:
  Solubility:DMSO:50 mg/mL (137.96 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zabludoff SD, et al. Mol Cancer Ther, 2008, 7(9), 2955-2966.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting