• Product NameMK-2461
• Brief DescriptionInhibitors
• Purification98.36%
• Biological ActivityMK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.
• Target Namec-Met/HGFR inhibitor
• CAS No. 917879-39-1
• Calculated MW 495.55
• Formulation C24H25N5O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C[C@@H]1COCCO1)S(=O)(=O)NC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O |r,c:16,18,21,25,27,34,t:14,23,30|
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Met (M1250T); c-Met (N1100); c-Met (Y1230C); c-Met (Y1230H); c-Met (Y1235D)
  Boling pt:
  Melting pt:
  Solubility:DMSO:99 mg/mL (199.77 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pan BS, et al. Cancer Res, 2010, 70(4), 1524-1533.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting