• Product NameGNF-5837
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGNF-5837 is a selective, and orally bioavailable pan-TRK inhibitor for TrkA, and TrkB with IC50 of 8 nM, and 12 nM, respectively.
• Target Namec-Kit inhibitor; PDGFR inhibitor; Trk receptor inhibitor
• CAS No. 1033769-28-6
• Calculated MW 535.49
• Formulation C28H21F4N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:Kit; PDGFRβ; TrkA; TrkB; TrkC
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (186.74 mM)Ethanol:9 mg/mL warmed (16.8 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Albaugh P, et al. ACS Med Chem Lett. 2012, 3(2), 140-145.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting