• Product NameCabotegravir (GSK744, GSK1265744)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
• Target NameHIV Protease inhibitor
• CAS No. 1051375-10-0
• Calculated MW 405.35
• Formulation C19H17F2N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C[C@H]1CO[C@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
  Pathways:Microbiology&virology; Proteases/Proteasome
  Receptor:HIV integrase
  Boling pt:
  Melting pt:
  Solubility:DMSO: 38 mg/mL warmed (93.74 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yoshinaga T, et al. Antimicrob Agents ChemOthers. 2015, 59(1), 397-406.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting