• Product NameGKT137831
• Brief DescriptionInhibitors
• Purification93.47%
• Biological ActivityGKT137831 is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Phase 2.
• Target NameNADPH-oxidase inhibitor
• CAS No. 1218942-37-0
• Calculated MW 394.85
• Formulation C21H19ClN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(C)C1=CC=CC(=C1)C1=C2C(NN(C2=O)C2=CC=CC=C2Cl)=CC(=O)N1C
  Pathways:Immunology/Inflammation
  Receptor:NOX1; NOX4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 78 mg/mL warmed (197.54 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Aoyama T, et al. Hepatology. 2012, 56(6), 2316-2327.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting