• Product NameTorin 2
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTorin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
• Target NameATM/ATR inhibitor; DNA-PK inhibitor; mTOR inhibitor
• CAS No. 1223001-51-1
• Calculated MW 432.4
• Formulation C24H15F3N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC=C(C=C1)C1=CC2=C3N(C(=O)C=CC3=CN=C2C=C1)C1=CC=CC(=C1)C(F)(F)F
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATM; ATR; DNA-PK; mTOR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL (46.25 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu Q, et al. J Med Chem, 2011, 54(5), 1473-1480.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting