• Product NameVS-5584 (SB2343)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1246560-33-7
• Calculated MW 354.41
• Formulation C17H22N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)N1C(C)=NC2=C1N=C(N=C2C1=CN=C(N)N=C1)N1CCOCC1 |c:5,7,10,12,20,t:15,17|
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO:71 mg/mL (200.33 mM)Ethanol:3 mg/mL (8.46 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. JA Pachter, et al. Molecular Targets and Cancer Therapeutics, 2012, abstract 405.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting