• Product NameKi16425
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityKi16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6.
• Target NameLPA Receptor antagonist
• CAS No. 355025-24-0
• Calculated MW 474.96
• Formulation C23H23ClN2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(OC(=O)NC1=C(ON=C1C)C1=CC=C(CSCCC(O)=O)C=C1)C1=CC=CC=C1Cl
  Pathways:GPCR/G Protein
  Receptor:LPA1; LPA2; LPA3
  Boling pt:
  Melting pt:
  Solubility:DMSO:95 mg/mL (200.01 mM)Ethanol:95 mg/mL (200.01 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ohta H, et al, Mol Pharmacol, 2003, 64(4), 994-1005.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting