• Product NameEX 527 (Selisistat)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
• Target NameSirtuin inhibitor
• CAS No. 49843-98-3
• Calculated MW 248.71
• Formulation C13H13ClN2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:NC(=O)C1CCCC2=C1NC1=C2C=C(Cl)C=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT1
  Boling pt:
  Melting pt:
  Solubility:DMSO:50 mg/mL (201.03 mM)Ethanol:18 mg/mL (72.37 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Solomon JM, et al. Mol Cell Biol, 2006, 26(1), 28-38.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting