• Product NameFostamatinib (R788)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityFostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
• Target NameAChR inhibitor; Adenosine Receptor inhibitor; Monoamine Transporter inhibitor; Syk inhibitor
• CAS No. 901119-35-5
• Calculated MW 580.46
• Formulation C23H26FN6O9P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC
  Pathways:Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
  Receptor:Adenosine transporter; A3; Monoamine transporter; Syk
  Boling pt:
  Melting pt:
  Solubility:DMSO: 116 mg/mL (199.84 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting