• Product NameTivantinib (ARQ 197)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTivantinib (ARQ 197) is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Phase 3.
• Target Namec-Met/HGFR inhibitor
• CAS No. 905854-02-6
• Calculated MW 369.42
• Formulation C23H19N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Met
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 12 mg/mL (32.48 mM); DMSO: 74 mg/mL (200.31 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Munshi N, et al. Mol Y Ther. 2010, 9(6), 1544-1553.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting