• Product NameHSP990 (NVP-HSP990)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.
• Target NameHSP inhibitor
• CAS No. 934343-74-5
• Calculated MW 379.39
• Formulation C20H18FN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=NC(=CC=C1)C1=C(C=CC(F)=C1)[C@H]1CC2=C(C(=O)N1)C(C)=NC(N)=N2 |r,c:4,6,11,14,19,26,29,t:2,9|
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP90α; HSP90β
  Boling pt:
  Melting pt:
  Solubility:DMSO:75 mg/mL (197.68 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Menezes DL, et al. Mol Cancer Ther, 2012, 11(3), 730-739.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting