• Product NameBLZ945
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs.
• Target NameCSF-1R inhibitor
• CAS No. 953769-46-5
• Calculated MW 398.48
• Formulation C20H22N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC(=O)C1=NC=CC(OC2=CC3=C(C=C2)N=C(N[C@@H]2CCCC[C@H]2O)S3)=C1 |r,c:6,12,14,29,t:4,10,17|
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:CSF-1R
  Boling pt:
  Melting pt:
  Solubility:DMSO:79 mg/mL (198.25 mM)Ethanol:3 mg/mL warmed (7.52 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pyonteck SM, et al. Nat Med. 2013, 19(10), 1264-1272.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting