• Product NamePralatrexate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
• Target NameDHFR inhibitor
• CAS No. 146464-95-1
• Calculated MW 477.47
• Formulation C23H23N7O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:NC1=NC(N)=C2N=C(CC(CC#C)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=NC2=N1 |r,c:15,17,32,35,t:1,4,6,13|
  Pathways:Metabolism
  Receptor:DHFR
  Boling pt:
  Melting pt:
  Solubility:DMSO:28 mg/mL (58.64 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Marchi E, et al. Clin Cancer Res, 2010, 16(14), 3648-3658.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting