• Product NameMubritinib (TAK 165)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk. Phase 1.
• Target NameEGFR inhibitor; FGFR inhibitor; JAK inhibitor; PDGFR inhibitor
• CAS No. 366017-09-6
• Calculated MW 468.47
• Formulation C25H23F3N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; HER2/ErbB2; FGFR; JAK1; PDGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO:13 mg/mL (27.74 mM)
  Appearance:Gray powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nagasawa J, et al. Int J Urol, 2006, 13(5), 587-592.;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting