• Product NameSemagacestat (LY450139)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySemagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. Phase 3.
• Target NameGamma-secretase inhibitor
• CAS No. 425386-60-3
• Calculated MW 361.44
• Formulation C19H27N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@H]1C2=C(CCN(C)C1=O)C=CC=C2 |r,c:14,23,25|
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Notch; γ secretase(Aβ38); γ secretase(Aβ40); γ secretase(Aβ42)
  Boling pt:
  Melting pt:
  Solubility:DMSO:72 mg/mL (199.2 mM)Ethanol:41 mg/mL (113.43 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mitani Y, et al. J Neurosci, 2012, 32(6), 2037-2050.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting