• Product NameRucaparib (AG-014699,PF-01367338)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. Phase 3.
• Target NamePARP inhibitor
• CAS No. 459868-92-9
• Calculated MW 421.36
• Formulation C19H18FN3O.H3PO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OP(O)(O)=O.CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=CC(F)=CC(N1)=C23 |c:9,11,14,24,t:7,21,28|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP
  Boling pt:
  Melting pt:
  Solubility:DMSO:84 mg/mL (199.35 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting