• Product NamePHA-665752
• Brief DescriptionInhibitors
• Purification99.35%
• Biological ActivityPHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs.
• Target NameBcr-Abl inhibitor; c-Met/HGFR inhibitor; FGFR inhibitor; VEGFR inhibitor
• CAS No. 477575-56-7
• Calculated MW 641.61
• Formulation C32H34Cl2N4O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C(=O)N2CCC[C@@H]2CN2CCCC2)C(C)=C(N1)\C=C1/C(=O)NC2=C1C=C(C=C2)S(=O)(=O)CC1=C(Cl)C=CC=C1Cl |r,c:1,19,28,31,33,40,43,45|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:c-Abl; c-Met; RON; FGFR1; Flk1
  Boling pt:
  Melting pt:
  Solubility:DMSO:128 mg/mL (199.49 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Christensen JG, et al. Cancer Res, 2003, 63(21), 7345-7355.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting