• Product NamePimasertib (AS-703026)
• Brief DescriptionInhibitors
• Purification98.15%
• Biological ActivityPimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2.
• Target NameMEK inhibitor
• CAS No. 1236699-92-5
• Calculated MW 431.2
• Formulation C15H15FIN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O
  Pathways:MAPK
  Receptor:MEK1/2 (MM cell line)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 86 mg/mL (199.44 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kim K, et al. Br J Haematol, 2010, 149(4), 537-549.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting