• Product NameYO-01027 (Dibenzazepine)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityYO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
• Target NameGamma-secretase inhibitor
• CAS No. 209984-56-5
• Calculated MW 463.48
• Formulation C26H23F2N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:γ secretase (APPL); γ secretase(Notch)
  Boling pt:
  Melting pt:
  Solubility:DMSO:92 mg/mL (198.49 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Groth C, et al, Mol Pharmacol, 2010, 77(4), 567-574.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting