• Product NameCX-6258
• Brief DescriptionInhibitors
• Purification97.98%
• Biological ActivityCX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.
• Target NamePim inhibitor
• CAS No. 1353859-00-3
• Calculated MW 498.4
• Formulation C26H24ClN3O3.HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl
  Pathways:Chromatin/Epigenetic; JAK/STAT signaling
  Receptor:Pim1; Pim2; Pim3
  Boling pt:
  Melting pt:
  Solubility:DMSO:57 mg/mL warmed (114.36 mM)Ethanol:1 mg/mL warmed (2.0 mM)Water89 mg/mL warmed (178.57 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Haddach M, et al. ACS Medicinal Chemistry Letters, 3 (2) , 135-139

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting