• Product NamePD318088
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
• Target NameMEK inhibitor
• CAS No. 391210-00-7
• Calculated MW 561.09
• Formulation C16H13BrF3IN2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OCC(O)CONC(=O)C1=C(NC2=CC=C(I)C=C2F)C(F)=C(F)C(Br)=C1 |c:9,17,26,t:12,14,22|
  Pathways:MAPK
  Receptor:MEK1; MEK2
  Boling pt:
  Melting pt:
  Solubility:DMSO:112 mg/mL (199.61 mM)Ethanol:14 mg/mL (24.95 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ohren JF, et al. Nat Struct Mol Biol, 2004, 11(12), 1192-1197.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting