• Product NameIcotinib
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityIcotinib is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR, EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).
• Target NameEGFR inhibitor
• CAS No. 610798-31-7
• Calculated MW 391.42
• Formulation C22H21N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C#CC1=CC(NC2=NC=NC3=CC4=C(OCCOCCOCCO4)C=C23)=CC=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO:78 mg/mL (199.27 mM)Ethanol:7 mg/mL (17.88 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tan F, et al. Lung Y, 2012, 76(2), 177-182.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting