• Product NameSU11274
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
• Target NameCDK inhibitor; c-Met/HGFR inhibitor; FGFR inhibitor; VEGFR inhibitor
• CAS No. 658084-23-2
• Calculated MW 568.09
• Formulation C28H30CIN5O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
  Receptor:CDK2; Met; RON; FGFR1; Flk1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (3.52 mM); DMSO: 92 mg/mL (161.94 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang X, et al. Mol Y Ther, 2003, 2(11):1085-1092.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting