• Product NameS-Ruxolitinib (INCB018424)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityS-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.
• Target NameChk inhibitor; JAK inhibitor; Tyrosine Kinases inhibitor
• CAS No. 941685-37-6
• Calculated MW 306.37
• Formulation C17H18N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:N#CC[C@@H](C1CCCC1)N1C=C(C=N1)C1=NC=NC2=C1C=CN2 |r,c:11,13,18,20,23,t:16|
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:Chk2; JAK1; JAK2; JAK3; Tyk2
  Boling pt:
  Melting pt:
  Solubility:DMSO:61 mg/mL (199.1 mM)Ethanol:61 mg/mL (199.1 mM)Water:5 mg/mL (16.32 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Quintas-Cardama A, et al. Blood, 2010, 115(15), 3109-3117.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting