• Product NameLDN-193189 HCl
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLDN193189 HCl is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β.
• Target NameALK inhibitor
• CAS No. 1062368-62-0
• Calculated MW 442.94
• Formulation C25H22N6.HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.C1CN(CCN1)C1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=C1C=CC=C2 |c:9,11,17,19,22,27,29,32,34,t:7,14,25|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK2; ALK3
  Boling pt:
  Melting pt:
  Solubility:DMSO:<1 mg/mL (<1 mM)Ethanol:<1 mg/mL (<1 mM)Water52 mg/mL (117.39 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Horbelt D, et al. J Biol Chem. 2015 Feb 6;290(6):3390-404.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting