• Product NameVU 0364439
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
• Target NameGluR modulator
• CAS No. 1246086-78-1
• Calculated MW 422.29
• Formulation C18H13Cl2N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl
  Pathways:Neuroscience
  Receptor:mGluR4
  Boling pt:
  Melting pt:
  Solubility:DMSO:85 mg/mL (201.28 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Engers DW, et al. Bioorg Med Chem Lett, 2010, 20(17), 5175-5178.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting