• Product NameTubastatin A HCl
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTubastatin A HCl is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
• Target NameHDAC inhibitor
• CAS No. 1310693-92-5
• Calculated MW 371.86
• Formulation C20H21N3O2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
  Boling pt:
  Melting pt:
  Solubility:DMSO:74 mg/mL (198.99 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Butler KV, et al, J Am Chem Soc, 2010, 132(31), 10842-10846.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting