• Product NameTelatinib
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTelatinib is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively. Phase 2.
• Target Namec-Kit inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 332012-40-5
• Calculated MW 409.83
• Formulation C20H16ClN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CNC(=O)C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C3=C2OC=C3)=C1 |c:6,21,24,28,30,t:4,11,13,16,18|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; PDGFRα; VEGFR2; VEGFR3
  Boling pt:
  Melting pt:
  Solubility:DMSO:82 mg/mL (200.08 mM)Ethanol:1 mg/mL (2.44 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Steeghs N, et al. Clin Cancer Res, 2008, 14(11), 3470-3476.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting