• Product NameSU9516
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively.
• Target NameCDK inhibitor; p38 MAPK inhibitor; PKC inhibitor
• CAS No. 377090-84-1
• Calculated MW 241.25
• Formulation C13H11N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC\2=C(C=C1)NC(=O)/C2=C\C3=CN=CN3
  Pathways:Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK
  Receptor:CDK1; CDK2; CDK4; p38; PKC
  Boling pt:
  Melting pt:
  Solubility:DMSO:48 mg/mL (198.96 mM)Ethanol:12 mg/mL warmed (49.74 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lane ME, et al. Cancer Res. 2001, 61(16), 6170-6177.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting