• Product NameZSTK474
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3Kδ. Phase1/2.
• Target NamePI3K inhibitor
• CAS No. 475110-96-4
• Calculated MW 417.41
• Formulation C19H21F2N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology/ Cancer
  SMILES:FC(F)C1=NC2=CC=CC=C2N1C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3K; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO:21 mg/mL (50.31 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yaguchi S, et al. J Natl Y Inst, 2006, 98(8), 545-556.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting