• Product NameBI-D1870
• Brief DescriptionInhibitors
• Purification99.26%
• Biological ActivityBI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
• Target NameS6 Kinase inhibitor
• CAS No. 501437-28-1
• Calculated MW 391.42
• Formulation C19H23F2N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)CCN1C(C)C(=O)N(C)C2=CN=C(NC3=CC(F)=C(O)C(F)=C3)N=C12
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:RSK1; RSK2; RSK3; RSK4
  Boling pt:
  Melting pt:
  Solubility:DMSO:78 mg/mL (199.27 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting