• Product NameBI 2536
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
• Target Namec-Met/HGFR inhibitor; PI3K inhibitor; PLK inhibitor
• CAS No. 755038-02-9
• Calculated MW 521.66
• Formulation C28H39N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
  Pathways:Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
  Receptor:Met; PI3Kα; PLK1; PLK2; PLK3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (191.69 mM); DMSO: 21 mg/mL (40.25 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Steegmaier M, et al. Curr Biol, 2007, 17(4), 316-322.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting