• Product NameR406
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityR406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.
• Target NameSyk inhibitor
• CAS No. 841290-81-1
• Calculated MW 628.63
• Formulation C22H23FN6O5C6H6O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular system
  SMILES:OS(=O)(=O)C1=CC=CC=C1.COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4)C=C3)=N2)=CC(OC)=C1OC
  Pathways:Angiogenesis
  Receptor:Syk
  Boling pt:
  Melting pt:
  Solubility:DMSO:126 mg/mL (200.43 mM)Ethanol:8 mg/mL (12.72 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting