• Product NamePF-00562271
• Brief DescriptionInhibitors
• Purification99.01%
• Biological ActivityPF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
• Target NameCDK inhibitor; FAK inhibitor; PYK2 inhibitor
• CAS No. 939791-38-5
• Calculated MW 665.66
• Formulation C21H20F3N7O3S.C6H6O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OS(=O)(=O)C1=CC=CC=C1.CN(C1=C(CNC2=C(C=NC(NC3=CC=C4NC(=O)CC4=C3)=N2)C(F)(F)F)C=CC=N1)S(C)(=O)=O |c:6,8,12,18,31,33,40,42,t:4,16,22,24|
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:CDK1/CyclinB; CDK2/CyclinE; CDK3/CyclinE; FAK; PYK2
  Boling pt:
  Melting pt:
  Solubility:DMSO:14 mg/mL warmed (21.03 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Roberts WG, et al. Cancer Res. 2008, 68(6), 1935-1944.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting