• Product NameUPF 1069
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityUPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
• Target NamePARP inhibitor
• CAS No. 1048371-03-4
• Calculated MW 279.29
• Formulation C17H13NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C(COC1=C2C=CNC(=O)C2=CC=C1)C1=CC=CC=C1 |c:4,6,12,14,19,21,t:17|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1; PARP2
  Boling pt:
  Melting pt:
  Solubility:DMSO:56 mg/mL (200.5 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Moroni F, et al. Br J Pharmacol, 2009, 157(5), 854-862.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting