• Product NameISRIB (trans-isomer)
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.
• Target NameERK inhibitor
• CAS No. 1597403-47-8
• Calculated MW 451.34
• Formulation C22H24Cl2N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
  Pathways:MAPK
  Receptor:PERK
  Boling pt:
  Melting pt:
  Solubility:DMSO:4 mg/mL (8.86 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sidrauski C, et al. Elife. 2013, 2, e00498.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting