• Product NameTSU-68 (SU6668, Orantinib)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTSU-68 (SU6668, Orantinib) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
• Target NameFGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
• CAS No. 252916-29-3
• Calculated MW 310.35
• Formulation C18H18N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(NC(=C1CCC(=O)O)C)/C=C/2\C3=CC=CC=C3NC2=O
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; PDGFRβ; Flk1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 62 mg/mL (199.77 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Laird AD, et al. Y Res, 2000, 60(15), 4152-4160.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting