• Product NameGambogic Acid
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
• Target NameBCL inhibitor; Bcr-Abl inhibitor
• CAS No. 2752-65-0
• Calculated MW 628.75
• Formulation C38H44O8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C
  Pathways:Angiogenesis; Apoptosis; Cytoskeletal Signaling
  Receptor:Bfl-1; Mcl-1; Bcl-2; Bcl-B; Bcl-w
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (159.04 mM)Ethanol:100 mg/mL (159.04 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhai D, et al. Mol Y Ther, 2008, 7(6), 1639-1646.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting